Antagonizing Wnt and FGF receptors: an enemy from within (the ER).
editorial · Level V
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Abstract
In this issue of Cell, Yamamoto et al. (2005) describe a novel molecule, Shisa, which functions in the endoplastic reticulum (ER) to prevent maturation of Frizzled (Fz) serpentine receptors and fibroblast growth factor receptor (FGFR). Shisa thus antagonizes Wnt and FGF signaling cell-autonomously, thereby promoting anterior patterning in Xenopus.
Medical subject headings
- Endoplasmic Reticulum
- Intercellular Signaling Peptides and Proteins
- Membrane Proteins
- Receptors, Fibroblast Growth Factor
- Signal Transduction