Birth pangs: the stressful origins of lymphocytes.
review · Level V
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- Record sourced from PubMed, PMID 15690077.
- Also identified by PMC identifier 546430.
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Abstract
Inositol-requiring enzyme 1 (IRE1) is a transmembrane protein that signals from the ER and contributes to the generation of an active spliced form of the transcriptional regulator X-box-binding protein 1 (XBP1). XBP1 is required for the terminal differentiation of B lymphocytes into plasma cells, and IRE1 also participates in this differentiation event. A study in this issue of the JCI reveals, quite unexpectedly, that IRE1 is also required early in B lymphocyte development for the induction of the machinery that mediates Ig gene rearrangement.
Medical subject headings
- Cell Differentiation
- Endoplasmic Reticulum
- Lymphocyte Activation
- Lymphopoiesis
- Plasma Cells
- Signal Transduction