Rab27a: a new face in beta cell metabolism-secretion coupling.
review · Level V
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- Record sourced from PubMed, PMID 15690078.
- Also identified by PMC identifier 546431.
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Abstract
In pancreatic beta cells, not only insulin exocytosis per se, but translocation of beta granules toward the plasma membrane--an event upstream of exocytosis--are under the control of glucose. However, the molecular basis of this translocation has been poorly understood. Rab27a-mediated translocation of glucose-induced beta granules is reported in this issue of the JCI. Rab27a or its effector molecule may constitute a novel pharmacological target because potentiation of the Rab27a pathway is expected to restore beta cell glucose competency in patients with diabetes mellitus.
Medical subject headings
- Insulin
- Islets of Langerhans
- Secretory Vesicles
- rab GTP-Binding Proteins