HLA-B27 associated spondyloarthropathy, vasculitis, and amyloid enteropathy: response to infliximab.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 15693105.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In 2000 we described a patient with HLA-B27 associated spondyloarthropathy (SpA) and severe ascending aortitis requiring surgical intervention. Despite continued immunosuppressive therapy she developed narrowing of the distal part of the right subclavian artery and proximal axillary artery secondary to active vasculitis. In addition, biopsy-proven amyloid gastroenteropathy developed causing persistent diarrhea and iron deficiency anemia. Treatment with infliximab resulted in resolution of joint symptoms and rapid improvement in laboratory markers of inflammation. Diarrhea settled more gradually, such that her bowel habit had normalized 16 months after therapy commenced.
Medical subject headings
- Amyloidosis
- Antibodies, Monoclonal
- Antirheumatic Agents
- Aortitis
- Gastroenteritis
- HLA-B27 Antigen
- Spondylarthropathies