Zygomycosis after prolonged use of voriconazole in immunocompromised patients with hematologic disease: attention required.

Vigouroux, Stéphane; Morin, Odile; Moreau, Philippe; Méchinaud, Françoise; Morineau, Nadine; Mahé, Béatrice; Chevallier, Patrice; Guillaume, Thierry et al. · Clin Infect Dis · 2005

case_report · Level V

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Abstract

We describe 4 cases of zygomycosis that occurred after prolonged use of voriconazole in severely immunocompromised patients with hematologic disease. An invasive infection was present in 3 patients who died soon after the diagnosis at 12, 13, and 45 days. Physicians should be mindful of this potential risk after treatment with voriconazole.

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