Interleukin-12 receptor beta 1 chain deficiency in a child with disseminated tuberculosis.

Ozbek, Namik; Fieschi, Claire; Yilmaz, Bafak T; de Beaucoudrey, Ludovic; Demirhan, Beyhan; Feinberg, Jacqueline; Bikmaz, Yunus Emre; Casanova, Jean-Laurent · Clin Infect Dis · 2005

case_report · Level V

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Abstract

An 11-year-old girl who presented with disseminated tuberculosis associated with secondary hemophagocytosis received a diagnosis of interleukin-12 receptor beta 1 chain deficiency. This diagnosis of immunodeficiency should, therefore, be considered for children with disseminated tuberculosis, even in the absence of any personal or familial history of prior infection by weakly pathogenic Salmonella and Mycobacterium species.

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