Fatal varicella associated with selective natural killer cell deficiency.
case_report · Level V
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- Record sourced from PubMed, PMID 15756234.
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Abstract
A 2-year-old girl with recurrent severe varicella infections had a fatal outcome. Studies of cellular and humoral immunity were normal. No natural killer (NK) cells were detected, and NK activity was markedly decreased. The interleukin (IL)15/IL15R signaling pathway was intact. This case emphasizes the role of NK cells in controlling herpes viral infection.
Medical subject headings
- Chickenpox
- Encephalitis, Varicella Zoster
- Killer Cells, Natural