Validity of composite end points in clinical trials.

Montori, Victor M; Permanyer-Miralda, Gaietà; Ferreira-González, Ignacio; Busse, Jason W; Pacheco-Huergo, Valeria; Bryant, Dianne; Alonso, Jordi; Akl, Elie A et al. · BMJ · 2005

review · Level V

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Abstract

Use of composite end points as the main outcome in randomised trials can hide wide differences in the individual measures. How should you apply the results to clinical practice?

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