Illuminating the role of type I IFNs in colitis.
other · Level V
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- Record sourced from PubMed, PMID 15765141.
- Also identified by PMC identifier 1052017.
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Abstract
Recently, type I interferons IFN-alpha and IFN-beta (IFN-alpha/beta) have been evaluated in pilot clinical trials for the treatment of active ulcerative colitis. However, the underlying mechanisms that may contribute to a potential therapeutic effect are incompletely understood. A new study in this issue demonstrates a protective role for IFN-alpha/beta, induced by activation of a Toll-like receptor 9-dependent pathway, in a rodent model of experimental colitis.
Medical subject headings
- Colitis, Ulcerative
- Interferon-alpha
- Interferon-beta