Reduced replication: a call to ARMS.
editorial · Level V
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Abstract
In this issue of Cell, Lemoine et al. monitor chromosome instability in yeast cells with reduced levels of an essential replicative DNA polymerase. The authors identify a hotspot for chromosome aberrations reminiscent of fragile sites in human cells. This hotspot is composed of inverted Ty elements, which lead to a double-strand break under conditions of limited replication.
Medical subject headings
- Chromosomal Instability
- Chromosome Aberrations
- DNA Replication
- DNA-Directed DNA Polymerase
- Yeasts