Meningoencephalitis due to penicillin-resistant Streptococcus pneumoniae.

Vassal, T; Piot, O; Mallat, Z; Lesage, D; Guidet, B; Offenstadt, G · Intensive Care Med · 1992

case_report · Level V

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Abstract

The case of a 68-year-old man suffering from pneumococcal meningoencephalitis is reported. Antibacterial susceptibility tests revealed a multiply resistant pneumococcal strain. High doses of cefotaxime were necessary to sterilize the cerebrospinal fluid despite the achievement of a satisfactory level of antibiotic in the cerebrospinal fluid with moderate dosage. In France, as well as in many countries, high doses of third-generation cephalosporins such as cefotaxime or ceftriaxone should be administered for the initial therapy of suspected pneumococcal meningitis.

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