Expression of the carcinoembryonic antigen gene is inhibited by SOX9 in human colon carcinoma cells.
basic_science · Level V
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Abstract
The human carcinoembryonic antigen (CEA) is overexpressed in many types of human cancers and is commonly used as a clinical marker. In colon cancer, this overexpression protects cells against apoptosis and contributes to carcinogenesis. Therefore, CEA-expressing cells as well as CEA expression itself constitute potential therapeutic targets. In this report, we show that the transcription factor SOX9 down-regulates CEA gene expression and, as a probable consequence, induces apoptosis in the human colon carcinoma cell line HT29Cl.16E.
Medical subject headings
- Carcinoembryonic Antigen
- Colonic Neoplasms
- Gene Expression Regulation, Neoplastic
- High Mobility Group Proteins
- Transcription Factors