In situ identification of hepatitis C virus RNA in muscle.
case_series · Level IV
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- Record sourced from PubMed, PMID 15781833.
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Abstract
The authors examined skeletal muscle specimens from four patients with myositis and hepatitis C virus (HCV) infection. PCR analysis identified HCV RNA in muscle homogenates from two patients. In situ hybridization signals for HCV RNA were detected within muscle fibers as well as in infiltrating lymphocytes from the same patients. The results may relate to the pathomechanism of myositis in patients with HCV infection.