Is it always unethical to use a placebo in a clinical trial?

Stang, Andreas; Hense, Hans-Werner; Jöckel, Karl-Heinz; Turner, Erick H; Tramèr, Martin R · PLoS Med · 2005

review · Level V

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Abstract

Placebos are used in trials to conceal whether a treatment is being given or not and hence to control for the psychosomatic effects of offering treatment. Placebo-controlled trials are controversial. Critics of such trials argue that if a proven effective therapy exists, a placebo should not be used. But proponents argue that placebo trials are still crucial to prove the efficacy and safety of many treatments.

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