A MALDI-chip integrated system with a monitoring window.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 15791334.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The integration of a monitoring port along the microfluidic path of a MALDI-chip integrated device is described. Optimization of the microreactor design allows longer reaction and measuring times. The Schiff base reaction between 4-tert-butylaniline (1) and 4-tert-butylbenzaldehyde (2) in ethanol was carried out on-chip in the MALDI ionization chamber and the formed imine 3 was detected in real time, demonstrating the feasibility of the "monitoring window" approach. This preliminary result opens the way to on-chip kinetic studies by MALDI-MS, by opening multiple monitoring windows along the microchannel.
Medical subject headings
- Lab-On-A-Chip Devices
- Microfluidics
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization