Super pH-sensitive multifunctional polymeric micelle.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 15794620.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
To endow enhanced tumor specificity and endosome disruption property on the carrier, a multifunctional polymeric micelle was investigated. The micelle exposes the cell interacting ligand (biotin) on the surface under slightly acidic environmental conditions of various solid tumors and is internalized by biotin receptor-mediated endocytosis in a short time period. The micelle also showed pH-dependent dissociation, causing the enhanced release of doxorubicin from the carrier in early endosomal pH. The dissociated micellar components subsequently disrupt endosomal membrane.
Medical subject headings
- Adenocarcinoma
- Biotin
- Coated Materials, Biocompatible
- Drug Delivery Systems
- Lactates
- Nanostructures
- Polyethylene Glycols