Single DNA molecule detection using nanopipettes and nanoparticles.
basic_science · Level V
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- Record sourced from PubMed, PMID 15794633.
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Abstract
Single DNA molecules labeled with nanoparticles can be detected by blockades of ionic current as they are translocated through a nanopipette tip formed by a pulled glass capillary. The nanopipette detection technique can provide not only tools for detection and identification of single DNA and protein molecules but also deeper insight and understanding of stochastic interactions of various biomolecules with their environment.
Medical subject headings
- Biosensing Techniques
- DNA
- Electrochemistry
- Microfluidic Analytical Techniques
- Nanotechnology
- Nanotubes