Axis formation--beta-catenin catches a Wnt.
editorial · Level V
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Abstract
In this issue of Cell, the Heasman group implicates Wnt11 as a component of the canonical Wnt signaling pathway that specifies Xenopus laevis axis formation (Tao et al., 2005). This important work not only identifies a long-sought-after dorsalizing factor but also highlights the pivotal role of extracellular cofactors in specifying the activation of either canonical or noncanonical Wnt pathways.
Medical subject headings
- Body Patterning
- Cytoskeletal Proteins
- Glycoproteins
- Signal Transduction
- Trans-Activators
- Xenopus