Axon guidance: opposing EPHects in the growth cone.
review · Level V
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Abstract
Cells communicate with other cells via (trans) interaction between membrane-linked ephrins and Eph receptors. In this issue of Cell, Pfaff and colleagues (Marquardt et al., 2005) demonstrate that coexpressed ephrin-As and Ephs do not interact in cis but rather segregate into separate membrane domains, from which they signal opposing effects during motor axon guidance.
Medical subject headings
- Axons
- Ephrins
- Growth Cones
- Receptors, Eph Family