Positive Kveim test in patients with coexisting sarcoidosis and human immunodeficiency virus infection.

Amin, D N; Sperber, K; Brown, L K; Chusid, E D; Teirstein, A S · Chest · 1992

case_report · Level V

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Abstract

We present two cases of sarcoidosis complicated by HIV infection. Each case had a different level of sarcoidosis activity and coexisted with either an AIDS-related infection or a HIV-positive state. Manifestations of sarcoidosis were not apparent in the patient with the AIDS-defining opportunistic infection, but were active in the patient with asymptomatic HIV infection. Both patients had granulomatous reactions to Kveim antigen, and one had such a reaction following an AIDS-defining infection. These findings suggest that non-T-cell mechanisms may be involved in granuloma formation in sarcoidosis.

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