Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer.
review · Level V
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Abstract
The Hedgehog-GLI signaling pathway is important in animal development and tumorigenesis. Recent findings indicate that the growth and survival of human prostate cancer cells rely upon sustained signaling from the Hedgehog-GLI pathway. These findings have prompted a novel rational strategy for therapeutic treatment of prostate tumors, including metastatic tumors.
Medical subject headings
- Membrane Proteins
- Oncogene Proteins
- Prostatic Neoplasms
- Receptors, Cell Surface
- Trans-Activators
- Transcription Factors