Rate of progression of cognitive decline in Alzheimer's disease: effect of butyrylcholinesterase K gene variation.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 15834019.
- Also identified by PMC identifier 1739631.
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Abstract
To determine whether individuals with Alzheimer's disease (AD) and the K variant allele of butyrylcholinesterase have a slower rate of cognitive decline than those without the K variant allele of butyrylcholinesterase. The cognitive status of 339 community based subjects with AD was assessed with the Mini Mental State Examination at baseline and yearly over a three year follow up period. The rates of cognitive decline of subjects with and without the K variant allele were compared. Presence of the K allele was associated with a slower average rate of cognitive decline in subjects with severe AD. This finding is consistent with the suggestion that the K variant of butyrylcholinesterase has an important role in disease progression in AD, and this may have implications for treatment.
Medical subject headings
- Alzheimer Disease
- Butyrylcholinesterase
- Cognition Disorders