Melanoma genetics and the development of rational therapeutics.
review · Level V
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- Record sourced from PubMed, PMID 15841168.
- Also identified by PMC identifier 1070435.
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Abstract
Melanoma is a cancer of the neural crest-derived cells that provide pigmentation to skin and other tissues. Over the past 4 decades, the incidence of melanoma has increased more rapidly than that of any other malignancy in the United States. No current treatments substantially enhance patient survival once metastasis has occurred. This review focuses on recent insights into melanoma genetics and new therapeutic approaches being developed based on these advances.
Medical subject headings
- Melanoma
- Skin Neoplasms