Torsin A haplotype predisposes to idiopathic dystonia.

Clarimon, Jordi; Asgeirsson, Hilmir; Singleton, Andrew; Jakobsson, Finnbogi; Hjaltason, Haukur; Hardy, John; Sveinbjornsdottir, Sigurlaug · Ann Neurol · 2005

case_control · Level III

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Abstract

Previous work has suggested that in many neurological diseases genetic variability in the loci predisposing subjects to autosomal dominant disease contributes to the risk of sporadic disease. Here, using a population-based sample of dystonia cases, we show an association with the torsin A haplotype and sporadic idiopathic dystonia.

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