Large or multiple congenital melanocytic nevi: occurrence of cutaneous melanoma in 1008 persons.

Abstract

There is a dearth of information regarding the occurrence of cutaneous melanoma in a large cohort of persons with large congenital melanocytic nevi (LCMN) or multiple congenital melanocytic nevi (MCMN). The purpose of this article is to report our experience with 1008 persons having LCMN and MCMN. Information was evaluated that was obtained from a database of persons with LCMN or MCMN voluntarily submitted by the affected persons to a nevus support group, the Nevus Network. Of those with garment LCMN, 2.9% developed cutaneous melanoma associated with 0.8% deaths. Of those with LCMN on the head or extremity, 0.3% developed cutaneous melanoma associated with no deaths to date. Of the small number with MCMN without a giant nevus, 6.7% developed cutaneous melanoma. Attending physician confirmation of submitted information was unavailable. Conclusions LCMN and MCMN were associated with a low occurrence of cutaneous melanoma in our group.