Methotrexate-induced bullous acral erythema in a child.
case_report · Level V
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Abstract
Chemotherapy induced acral erythema (CIAE) is an uncommon and dramatic reaction to high-dose chemotherapy. It is characterized by symmetrical, well-demarcated, painful erythema of the palms and soles which may progress to bullae formation and desquamation. Prompt recognition and discrimination from more serious conditions such as graft-vs-host disease or toxic epidermal necrolysis is essential. This paper describes the case of a 12-year-old boy who developed CIAE after high-dose methotrexate treatment and discusses the important clinical, histopathological, and therapeutic features of this condition.
Medical subject headings
- Antimetabolites, Antineoplastic
- Femoral Neoplasms
- Methotrexate
- Osteosarcoma
- Skin Diseases, Vesiculobullous