Concentrated hydroxyapatite inks for direct-write assembly of 3-D periodic scaffolds.
biomechanical · Level V
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Abstract
Hydroxyapatite (HA) scaffolds with a 3-D periodic architecture and multiscale porosity have been fabricated by direct-write assembly. Concentrated HA inks with tailored viscoelastic properties were developed to enable the construction of complex 3-D architectures comprised of self-supporting cylindrical rods in a layer-by-layer patterning sequence. By controlling their lattice constant and sintering conditions, 3-D periodic HA scaffolds were produced with a bimodal pore size distribution. Mercury intrusion porosimetry (MIP) was used to determine the characteristic pore size and volume associated with the interconnected pore channels between HA rods and the finer pores within the partially sintered HA rods.
Medical subject headings
- Bone Substitutes
- Crystallization
- Extracellular Matrix
- Hydroxyapatites
- Ink
- Microfluidics
- Tissue Engineering