T cell regulation of the antibody response to bacterial polysaccharide antigens: an examination of some general characteristics and their implications.
review · Level V
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Abstract
The characteristics of thymus-derived (T) lymphocytes that regulate the magnitude of the antibody response to the capsular polysaccharide antigen of type III Streptococcus pneumoniae are considered within the context of a general homeostatic model for controlling the antibody response to microbial antigens of medical importance. Some experimental approaches are described in which the activities of such regulatory T cells are modulated to provide an increase in the development of host immunity, to improve the immunogenicity of poorly immunogenic antigens, or to eliminate the inhibitory effects of suppressor T cells.
Medical subject headings
- Antibodies, Bacterial
- Antigens, Bacterial
- Polysaccharides, Bacterial
- Streptococcus pneumoniae
- T-Lymphocytes