Translational repression by Bicoid: competition for the cap.
basic_science · Level V
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Abstract
Eggs and embryos have proven to be fertile grounds for discovery and characterization of a variety of mechanisms used in posttranscriptional control of gene expression, mechanisms that are central to embryonic patterning and development. In this issue of Cell, solve a puzzle surrounding the action of the Drosophila Bicoid morphogen in formation of the Caudal protein gradient and in doing so describe a novel mechanism of translational repression.
Medical subject headings
- Gene Expression Regulation, Developmental
- Homeodomain Proteins
- Protein Biosynthesis
- Trans-Activators