Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection.
prospective_cohort · Level II
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Abstract
Chronic granulomatous disease (CGD) is characterized by life-threatening bacterial and fungal infections. Treatment with posaconazole led to a complete response in 7 of 8 patients with CGD with invasive mold infections (7 proven cases and 1 possible case) after failure or intolerance of treatment with standard antifungal agents. In this preliminary study, salvage treatment with posaconazole was safe and effective.
Medical subject headings
- Antifungal Agents
- Fungi
- Granulomatous Disease, Chronic
- Lung Diseases, Fungal
- Salvage Therapy
- Triazoles