Adult metachromatic leukodystrophy with an unusual relapsing-remitting course.
case_report · Level V
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- Record sourced from PubMed, PMID 1589377.
- Also identified by PMC identifier 2399237.
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Abstract
A 46 year old woman had a relapsing-remitting course of hemiparesis, disorientation, paraparesis and seizures, followed by progressive dementia, spasticity and ataxia. Computed tomography at onset showed a parietotemporal hypodense area with diffuse mottled enhancement obliterating the lateral ventricle. Subsequent scans demonstrated symmetric periventricular non-enhancing hypodensities, progressive ventricular enlargement and atrophy. Adult metachromatic leukodystrophy was diagnosed on the basis of low leukocyte arylsulphatase A level and metachromatic material accumulation at neural nerve biopsy.
Medical subject headings
- Leukodystrophy, Metachromatic