AC electrospray biomaterials synthesis.
basic_science · Level V
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Abstract
A rapid, viable and safe fabrication method for biomaterials synthesis is reported using high-frequency AC electrospraying. We demonstrate its potential for polymeric nanoparticle fabrication, drug encapsulation in mono-dispersed micron-sized biodegradable polymer shells and the synthesis of 1microm biodegradable fibers with adjustable pore sizes as bioscaffolds for tissue/orthopaedic engineering and wound care therapy. The absence of charge in the ejected drops and fibers facilitates pulmonary drug delivery, polymer encapsulation and minimizes protein/DNA denaturing or compound ionization.
Medical subject headings
- Biocompatible Materials
- Crystallization
- Drug Carriers
- Electrochemistry
- Electromagnetic Fields
- Nanostructures
- Nanotechnology
- Polymers