A new view of an old pore.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 15907459.
- Also identified by DOI 10.1016/j.cell.2005.05.002.
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Abstract
Despite reports suggesting a potential role in membrane fusion, the V(0) subunit of the (+)H/ATPase has remained an unlikely candidate for the fusion pore. In this issue of Cell, Hiesinger and coworkers (Hiesinger et al., 2005) present a forward genetic screen that reveals it to be necessary for synaptic vesicle fusion, independent of its role in vesicle acidification.
Medical subject headings
- Membrane Fusion
- Synaptic Membranes
- Synaptic Vesicles
- Vacuolar Proton-Translocating ATPases