No rest for REST: REST/NRSF regulation of neurogenesis.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 15907461.
- Also identified by DOI 10.1016/j.cell.2005.05.003.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Epigenetic strategies control the orderly acquisition and maintenance of neuronal traits. A complex network of transcriptional repressors and co-repressors mediates gene specificity for these strategies. In this issue of Cell, a study by Ballas and coworkers (Ballas et al., 2005) provides insight into the early lineage commitment events during neurogenesis. This study demonstrates that regulation of the REST/NRSF transcriptional repressor plays a fundamental role in the progression of pluripotent cells to lineage-restricted neural progenitors.
Medical subject headings
- Cell Differentiation
- Nervous System
- Neurons
- Pluripotent Stem Cells
- Repressor Proteins
- Transcription Factors