Successful treatment of Fusarium keratitis with cornea transplantation and topical and systemic voriconazole.

Klont, Rocus R; Eggink, Cathrien A; Rijs, Antonius J M M; Wesseling, Pieter; Verweij, Paul E · Clin Infect Dis · 2005

case_report · Level V

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Abstract

A case of invasive Fusarium keratitis in a previously healthy male patient was treated successfully with cornea transplantation and systemic and topical voriconazole after treatment failure with topical amphotericin B and systemic itraconazole. Topical voriconazole was well tolerated, and, in conjunction with the oral administration, it resulted in a high level of the drug in the anterior chamber of the eye (which was 160% of the plasma drug level).

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