Does linezolid cause lactic acidosis by inhibiting mitochondrial protein synthesis?
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 15909253.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Linezolid, an oxazolidinone antibiotic, inhibits bacterial protein synthesis by binding to 23S ribosomal RNA (rRNA). We studied 3 patients who experienced lactic acidosis while receiving linezolid therapy. The toxicity may have been caused by linezolid binding to mitochondrial 16S rRNA. Genetic polymorphisms may have contributed to the toxicity in 2 patients.
Medical subject headings
- Acetamides
- Acidosis, Lactic
- Mitochondria
- Oxazolidinones
- Protein Biosynthesis