Trace elements and the electroencephalogram during long-term lithium treatment.

Harvey, N S; Jarratt, J; Ward, N I · Br J Psychiatry · 1992

case_control · Level III

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Abstract

Endogenous bromine has been found to be raised during lithium treatment, and it has been suggested that it may augment the therapeutic effect of lithium. Our findings in a study of 12 patients and 12 controls support this contention. Electroencephalographic effects of bromine, vanadium and aluminium were studied--higher bromine and vanadium levels were associated with irregular cortical activity. Electroencephalographic abnormalities were associated with more side-effects of lithium.

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