Using reconfigurable hardware to accelerate multiple sequence alignment with ClustalW.
basic_science · Level V
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- Record sourced from PubMed, PMID 15919726.
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Abstract
Aligning hundreds of sequences using progressive alignment tools such as ClustalW requires several hours on state-of-the-art workstations. We present a new approach to compute multiple sequence alignments in far shorter time using reconfigurable hardware. This results in an implementation of ClustalW with significant runtime savings on a standard off-the-shelf FPGA.
Medical subject headings
- Computers
- Sequence Alignment
- Sequence Analysis, Protein
- Signal Processing, Computer-Assisted
- Software
- User-Computer Interface