MeSHer: identifying biological concepts in microarray assays based on PubMed references and MeSH terms.
Where this comes from
- Record sourced from PubMed, PMID 15919728.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
MeSHer uses a simple statistical approach to identify biological concepts in the form of Medical Subject Headings (MeSH terms) obtained from the PubMed database that are significantly overrepresented within the identified gene set relative to those associated with the overall collection of genes on the underlying DNA microarray platform. As a demonstration, we apply this approach to gene lists acquired from a published study of the effects of angiotensin II (Ang II) treatment on cardiac gene expression and demonstrate that this approach can aid in the interpretation of the resulting 'significant' gene set. The software is available at http://www.tm4.org. Results from the analysis of significant genes from the published Ang II study.
Medical subject headings
- Database Management Systems
- Gene Expression Profiling
- Information Storage and Retrieval
- Medical Subject Headings
- Natural Language Processing
- Oligonucleotide Array Sequence Analysis
- PubMed
- Software