The effects of intravenous lidocaine on pain during injection of medium- and long-chain triglyceride propofol emulsions.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 15920197.
- Also identified by DOI 10.1213/01.ANE.0000151718.58709.0B.
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Abstract
Propofol formulated in medium- and long-chain triglycerides (MCT/LCT) is thought to cause less pain on injection. In this study we sought to determine if adding lidocaine to propofol-MCT/LCT is more effective in decreasing pain compared with propofol-MCT/LCT alone or conventional propofol-lidocaine mixtures. Seventy-five patients were randomized into three groups. Group A received conventional propofol-lidocaine mixtures with 20 mg lidocaine, group B received propofol-MCT/LCT with saline, and group C received propofol-MCT/LCT with 20 mg lidocaine. The incidence of pain was 24% in groups A and B and 4% in group C. The number needed to treat to prevent pain was 5. We conclude that propofol-MCT/LCT-lidocaine mixtures significantly reduce pain.
Medical subject headings
- Anesthetics, Intravenous
- Anesthetics, Local
- Lidocaine
- Pain
- Propofol