The mechanical properties of rat spinal cord in vitro.

Abstract

Freshly excised rat spinal cords were tested in uniaxial tension, in vitro, at strain rates ranging from 0.002 to 0.2 s-1. Stress relaxation tests were performed for a range of strains from 2% to 5%, with the relaxation behaviour being recorded for a period of at least 30 min. Samples exhibited a characteristic "J" shaped non-linear stress-strain response, with stiffness increasing with applied strain. The cords were labelled with rows of small markers and the uniaxial tension tests were recorded via video. Subsequent image analysis enabled the distribution of strain on the cord surface to be determined. Viscoelastic models were developed to model the mechanical behaviour of the specimens and were found to adequately describe the material behaviour.