Developmental toxicity of the angiotensin II type 1 receptor antagonists during human pregnancy: a report of 10 cases.

Abstract

Angiotensin II type 1 receptor antagonists (ARA). Interacted with the renin-angiotensin system, and the present study was undertaken to examine their fetal and neonatal toxicity when taken by the mother during pregnancy. Prospective follow up of pregnant women exposed to an ARA during early pregnancy. The present study was conducted in the departments of Paedriatric Pharmacology of the University hospital Robert Debre in Paris, France. Ten women exposed to an ARA during early pregnancy. Prospective follow up. Fetal ultrasonography and outcome of pregnancy. Prenatal ultrasonography showed abnormal features in five cases (oligoamnios related to fetal tabular dysgenesis, fetal dysmorphia and renal abnormalities). Outcome of pregnancy was as follows: three induced abortions, two stillbirths (twin pregnancy), one neonate presenting with dysmorphia and renal disease and five neonates with an uneventful development. Women of reproductive age should be advised of the possible hazards of ARA and treatment should be stopped as soon as pregnany has been documented.