Factors affecting statistical power in the detection of genetic association.
review · Level V
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- Record sourced from PubMed, PMID 15931375.
- Also identified by PMC identifier 1137002.
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Abstract
The mapping of disease genes to specific loci has received a great deal of attention in the last decade, and many advances in therapeutics have resulted. Here we review family-based and population-based methods for association analysis. We define the factors that determine statistical power and show how study design and analysis should be designed to maximize the probability of localizing disease genes.
Medical subject headings
- Genetic Predisposition to Disease
- Linkage Disequilibrium
- Lod Score
- Models, Genetic
- Quantitative Trait, Heritable