Linkage disequilibrium maps and association mapping.
review · Level V
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- Record sourced from PubMed, PMID 15931377.
- Also identified by PMC identifier 1137007.
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Abstract
The causal chain between a gene and its effect on disease susceptibility cannot be understood until the effect has been localized in the DNA sequence. Recently, polymorphisms incorporated in the HapMap Project have made linkage disequilibrium (LD) the most powerful tool for localization. The genetics of LD, the maps and databases that it provides, and their use for association mapping, as well as alternative methods for gene localization, are briefly described.
Medical subject headings
- Genetic Predisposition to Disease
- Genome, Human
- Linkage Disequilibrium
- Physical Chromosome Mapping
- Polymorphism, Single Nucleotide