Ovarian transplantation between monozygotic twins discordant for premature ovarian failure.
case_report · Level V
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- Record sourced from PubMed, PMID 15941849.
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Abstract
Monozygotic 24-year-old twins presented with discordant ovarian function. One had had premature ovarian failure at the age of 14 years, whereas her sister had normal ovaries and three naturally conceived children. After unsuccessful egg-donation therapy, the sterile twin received a transplant of ovarian cortical tissue from her sister by means of a minilaparotomy. Within three months after transplantation, the recipient's cycles resumed and serum gonadotropin levels fell to the normal range. During the second cycle, she conceived, and her pregnancy progressed uneventfully. At 38 weeks' gestation, she delivered a healthy-appearing female infant.
Medical subject headings
- Diseases in Twins
- Infertility, Female
- Ovary
- Pregnancy
- Primary Ovarian Insufficiency