Diclofenac does not modify morphine bioavailability in cancer patients.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 1594262.
- Also identified by DOI 10.1016/0304-3959(92)90091-O.
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Abstract
We determined morphine plasma concentrations in 6 cancer patients before and with administration of diclofenac for 5 days. The non-steroidal anti-inflammatory drug does not modify morphine bioavailability. This observation suggests that diclofenac can be used in association with morphine during cancer pain treatment, without increasing the risk of overdosage or side effects of the opiate.
Medical subject headings
- Diclofenac
- Morphine
- Neoplasms
- Pain