Optical and MRI multifunctional nanoprobe for targeting gliomas.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 15943433.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A multifunctional nanoprobe capable of targeting glioma cells, detectable by both magnetic resonance imaging and fluorescence microscopy, was developed. The nanoprobe was synthesized by coating iron oxide nanoparticles with covalently bound bifunctional poly(ethylene glycol) (PEG) polymer, which were subsequently functionalized with chlorotoxin and the near-infrared fluorescing molecule Cy5.5. Both MR imaging and fluorescence microscopy showed significant preferential uptake of the nanoparticle conjugates by glioma cells. Such a nanoprobe could potentially be used to image resections of glioma brain tumors in real time and to correlate preoperative diagnostic images with intraoperative pathology at cellular-level resolution.
Medical subject headings
- Brain Neoplasms
- Ferric Compounds
- Glioma
- Magnetic Resonance Imaging
- Microscopy, Fluorescence
- Nanotechnology
- Polyethylene Glycols