Optimal protein-folding codes from spin-glass theory.
basic_science · Level V
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- Record sourced from PubMed, PMID 1594594.
- Also identified by PMC identifier 49199.
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Abstract
Protein-folding codes embodied in sequence-dependent energy functions can be optimized using spin-glass theory. Optimal folding codes for associative-memory Hamiltonians based on aligned sequences are deduced. A screening method based on these codes correctly recognizes protein structures in the "twilight zone" of sequence identity in the overwhelming majority of cases. Simulated annealing for the optimally encoded Hamiltonian generally leads to qualitatively correct structures.
Medical subject headings
- DNA-Binding Proteins
- Protein Conformation