Corticotropin-releasing hormone-induced seizures in infant rats originate in the amygdala.
basic_science · Level V
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- Record sourced from PubMed, PMID 1596084.
- Also identified by PMC identifier 3153947.
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Abstract
The neuroanatomical substrate of seizures induced by picomolar amounts of corticotropin-releasing hormone in infant rats was investigated. Electrographic and behavioral phenomena were monitored in 42 rat pups aged 5 to 22 days. Rat pups carried bipolar electrodes implanted in subcortical limbic structures, as well as cortical electrodes and intracerebroventricular cannulae. The administration of corticotropin-releasing hormone produced age-specific seizures within minutes, which correlated with rhythmic amygdala discharges. Paroxysmal hippocampal and cortical discharges developed subsequently in some rats. Corticotropin-releasing hormone-induced electrographic and behavioral seizures originate in the amygdala.
Medical subject headings
- Amygdala
- Corticotropin-Releasing Hormone
- Seizures