DNA-BAR: distinguisher selection for DNA barcoding.
basic_science · Level V
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- Record sourced from PubMed, PMID 15961439.
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Abstract
DNA-BAR is a software package for selecting DNA probes (henceforth referred to as distinguishers) that can be used in genomic-based identification of microorganisms. Given the genomic sequences of the microorganisms, DNA-BAR finds a near-minimum number of distinguishers yielding a distinct hybridization pattern for each microorganism. Selected distinguishers satisfy user specified bounds on length, melting temperature and GC content, as well as redundancy and cross-hybridization constraints.
Medical subject headings
- Algorithms
- Chromosome Mapping
- DNA
- In Situ Hybridization
- Sequence Analysis, DNA
- Software